Riad Agbaria Selected Research

(north)-methanocarbathymidine

1/2007	Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
9/2006	The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent.
5/2005	Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture.
11/2002	Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
7/2002	Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells.
6/2002	Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.

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Riad Agbaria Research Topics

Disease

10	Neoplasms (Cancer) 08/2007 - 06/2002
6	Colonic Neoplasms (Colon Cancer) 12/2010 - 06/2002
4	Herpes Simplex 05/2007 - 06/2002
2	Carcinoma (Carcinomatosis) 01/2015 - 07/2005
2	Infections 05/2005 - 07/2002
2	Virus Diseases (Viral Diseases) 05/2005 - 07/2002
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Hodgkin Disease (Hodgkin's Disease) 01/2015
1	Glioblastoma (Glioblastoma Multiforme) 12/2010
1	Osteosarcoma (Osteogenic Sarcoma) 09/2006

Drug/Important Bio-Agent (IBA)

7	Thymidine KinaseIBA 12/2010 - 06/2002
6	(north)-methanocarbathymidineIBA 01/2007 - 06/2002
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2003
4	ThymidineIBA 05/2007 - 06/2002
3	pyrimidin-2-one beta-ribofuranosideIBA 11/2005 - 01/2005
3	ProdrugsIBA 12/2004 - 06/2002
2	NF-kappa B (NF-kB)IBA 01/2015 - 12/2010
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2010 - 12/2004
2	Antineoplastic Agents (Antineoplastics)IBA 11/2005 - 01/2005
2	Pharmaceutical PreparationsIBA 07/2005 - 11/2002
2	Ganciclovir (Cytovene)FDA LinkGeneric 12/2004 - 07/2002
2	EnzymesIBA 12/2003 - 11/2002
1	Organic Anion TransportersIBA 01/2018
1	CationsIBA 01/2018
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2018
1	thymoquinoneIBA 01/2015
1	Nigella sativa oilIBA 01/2015
1	Insulin-Like PeptidesIBA 08/2007
1	LycopeneIBA 08/2007
1	Insulin-Like Growth Factor I (IGF-1)IBA 08/2007
1	bicyclo(3.1.0)hexaneIBA 05/2007
1	Conditioned Culture MediaIBA 01/2007
1	triphosphoric acid (triphosphate)IBA 01/2007
1	Antiviral Agents (Antivirals)IBA 09/2006
1	ProstaglandinsIBA 12/2004
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2004
1	nimesulide (Aulin)IBA 12/2004
1	Prostaglandins EIBA 12/2004
1	Neomycin FDA LinkGeneric 12/2004
1	Carotenoids (Carotene)IBA 12/2003
1	CyclinsIBA 12/2003
1	ConnexinsIBA 12/2003
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 12/2003
1	5- carboxy- methylaminomethyl- 2'- O- methyluridineIBA 11/2002
1	CarbasugarsIBA 06/2002
1	Cytostatic AgentsIBA 06/2002

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 11/2005 - 01/2005
2	Oral Administration 11/2005 - 01/2005
1	Colectomy 08/2007
1	Transplantation 01/2007
1	Therapeutics 09/2006